Insulin resistance and Parkinson’s disease: A new target for disease modification?

Insulin resistance in the brain: A new therapeutic target for Alzheimer's disease

Alzheimer’s disease (AD) is the most common form of dementia, accounting for more than 50% of cases at autopsy and in clinical series. The incidence of the disease doubles every 5 years after 65 years-of-age. With the aging of the population, the number of AD patients continues to increase. AD affects memory and other cognitive domains, leading to the subsequent deprivation of independence in d...

Insulin Resistance and Alzheimer’s Disease

Insulin resistance and Alzheimer's disease.

Emerging data demonstrate pivotal roles for brain insulin resistance and insulin deficiency as mediators of cognitive impairment and neurodegeneration, particularly Alzheimer's disease (AD). Insulin and insulin-like growth factors (IGFs) regulate neuronal survival, energy metabolism, and plasticity, which are required for learning and memory. Hence, endogenous brain-specific impairments in insu...

Insulin resistance and coronary artery disease in non-diabetic patients: Is there any correlation?

Background: Cardiovascular diseases are the most common causes of death in the world and type 2 diabetes is one of them because it is highly prevalent and doubles heart disease risk. Some studies suggest that insulin resistance is associated with coronary artery disease in non-diabetics. The aim of this study was to evaluate the association of insulin resistance (IR) and coronary artery disease...

Papaya Dieback in Malaysia: A StepTowards A New Insight of Disease Resistance

A recently published article describing the draft genome of Erwiniamallotivora BT-Mardi (1), the causal pathogen of papaya dieback infection in Peninsular Malaysia, hassignificant potential to overcome and reduce the effect of this vulnerable crop (2). The authors found that the draft genome sequenceis approximately 4824 kbp and the G+C content of the genomewas 52-54%, which is very similarto t...